Applications at the end of the project

Papers published in ISI journals

1.  In vitro Cytotoxicity, Corrosion and Antibacterial Efficiencies of Zn Doped Hydroxyapatite Coated Ti Based Implant Materials, S. Buyuksungur, P.Y. Huri, J. Schmidt, I. Pana, M. Dinu, C. Vitelaru, A.E. Kiss, D.G. Tamay, V. Hasirci, A. Vladescu, N. Hasirci, Ceramics International, (2023), doi: 10.1016/j.ceramint.2022.12.119

2.  Zn doped CaP coatings used for controlling the degradation rate of MgCa1 alloy: in vitro anticorrosive properties, sterilization and bacteria-/cell-material interactions, J. Schmidt, I. Pana, A. Bystrova, M. Dinu, Y. Dekhtyar, C. Vitelaru, M. Gorohovs, I.M. Marinescu, P.Y. Huri, D.G. Tamay, G.A. Juravlea, S. Buyuksungur, A.C. Parau, V. Hasirci, N. Hasirci, A. Vladescu, Colloids and Surfaces B: Biointerfaces, 222 (2023) 1-12, doi: 10.1016/j.colsurfb.2022.113087

3.  Corrosion resistance and cytocompatibility of magnesium-calcium alloys modified with zinc- or gallim-doped calcium phosphate coatings, D.G. Tamay, S. Gokyer, J. Schmidt, A. Vladescu, P.Y. Huri, V. Hasirci, N. Hasirci, ACS Applied Materials & Interfaces 14 (2022) 104-122, doi: 10.1021/acsami.1c16307

Results 2021

Patent

1.  A patent application is in progress.

Prototypes

Screws made of Ti6Al7Nb (Tehnomed Impex SA - Romania and Sintel - Russia) and coated by INOE

Papers published in ISI journals

1. Evaluation of surface modification techniques on the ability of apatite formation and corrosion behavior in synthetic body fluid: an in vitro study, C.M. Cotrut, I.C. Ionescu, E. Ungureanu, A. Berbecaru, R.I. Zamfir, A. Vladescu, D.M. Vranceanu, Surfaces and Interfaces 22 (2021) 1-12, doi: 10.1016/j.surfin.2020.100866  (IF2020= 4.837, Q1). 
2. Zn-Doped CaP-Based Coatings on Ti–6Al–4V and Ti–6Al–7Nb Alloys Prepared by Magnetron Sputtering: Controllable Biodegradation, Bacteriostatic, and Osteogenic Activities, K.A. Prosolov, D.V. Mitrichenko, A.B. Prosolov, O.O. Nikolaeva , V.V. Lastovka, O.A. Belyavskaya, V.A. Chebodaeva, I.A. Glukhov, L.S. Litvinova, V.V. Shupletsova, O.G. Khaziakhmatova, V.V. Malashchenko, K.A. Yurova, E.O. Shunkin, M.A. Fedorov, A.R. Komkov, V.V. Pavlenko, I.I. Anisenya, Y.P.Sharkeev, A. Vladescu, I.A. Khlusov, Coatings 11 (2021) 809, doi: 10.3390/coatings11070809 (IF2020= 2.881, Q2). 

ISI papers under review:

1. Corrosion resistance and biocompatibility of calcium phosphate coatings doped with zinc and gallium on micro-arc oxidized magnesium-calcium alloys, D.G.Tamay, S.Gokyer, J.Schmidt, A.Vladescu, P.Y.Huri, V.Hasirci, N.Hasirci, Journal of Magnesium and Alloys (IF2020=10.088, Q1)

ISI papers under development (delay due to the patent application):

1. MgCa1 alloy coated by CaP coatings used for biodegradable implants, J. Schmidt, I.Pana, M. Dinu, Ş.Gokyer, P.Y.Huri, N.Hasirci, A.Vladescu, et al., it will be submitted to Acta Biomaterialia 2021 (IF2020=8.947, Q1)
2. Solution for decreasing of corrosion rate of MgCa alloy used in biomedical applications, A.Vladescu, J. Schmidt, D. Kloss, P.Y. Huri et al., Ceramics International 2021 (IF2020=4.527, Q1)

Papers presented at international conferences

Invited papers:

1. Degradation of sputtered hydroxyapatite in different acellular media, A. Vladescu, C.M. Cotrut, I. Pana, E. Ungureanu, D.M. Vranceanu, 1st Corrosion and Materials Degradation Web Conference CMDWC 2021- Symposium S9 Corrosion and Degradation of Biomaterials, 17 - 19 May 2021, online
2. Solution for decreasing of corrosion rate of MgCa alloy used in biomedical applications, A. Vladescu, J. Schmidt, P.Y. Huri, C. Vitelaru, D. Kloss, N. Hasirci, V. Hasirci, L.R. Constantin, M. Braic, EMRS Spring Meeting, 31 May – 4 June 2021, online

Consortium meetings

• 2 March 2021 – online meeting; participants: dr. eng. Alina Vladescu (INOE2000), dr. Julia Kzhyshkowska (University of Heidelberg, Germany) and eng. Jürgen Schmidt (INNOVENT, Germany).
• 19 March 2021 – online meeting; participants: dr. eng. Alina Vladescu (INOE2000), dr. Julia Kzhyshkowska (University of Heidelberg, Germany) and eng. Jürgen Schmidt (INNOVENT, Germany).
• 7 April 2021 – online meeting; participants: dr. eng. Alina Vladescu (INOE2000), dr. Julia Kzhyshkowska (University of Heidelberg, Germany) and eng. Jürgen Schmidt (INNOVENT, Germany).

All meetings were organized online due to the reinstructions imposed by pandemic Covid-19.

Student projects

Bachelor project –July 2021: Ioana Maria Marinescu "Improvement of degradation rate of MgCa1 alloys by coatings with sputtered hydroxyapatite"

Dissertation project –July 2021: Gabriela Juravlea “Coatings based hydroxyapatite doped Mg to control of corrosion of Mg alloys”

Young people involved in project

4 postdocs: C.Vitelaru, M.Dinu, A.Parau, I.Pana, L. Constantin (2020)
1 PhD student: E. Ungureanu

Visibility of project

Announcement on LinkedIN of Alina Vladescu:>https://www.linkedin.com/feed/update/urn:li:ugcPost:6699304535552212992/

Announcement on ResearchGate of Alina Vladescu: https://www.researchgate.net/project/CoatDegraBac-project-COFUND-ERANET-RUS-PLUS-68-01082018

Results 2020

Patent

1.  Patent application no. A/00120/04.03.2020, Nanostructured thin films used in industrial applications and/or medicine, A. Vladescu, A. C.Parau, C. Vitelaru, I. Pana, L.R.Constantin

Awards

For patent application no. A/00120/ 04.03.2020, Nanostructured thin films used in industrial applications and/or medicine, A. Vlădescu, A. C. Pârău, C. Vițelaru, I. Pană, L. R.Constantin:

1. Diploma of Achievement at Medal Inventica 2020 at The 24th International Exhibition of Inventions - INVENTICA 2020, 29 -31 July 2020, Iasi, Romania, ONLINE
2. Gold Medalat International Exhibition for Inventions and Innovations ,,TRAIAN  VUIA” Timișoara, edition VI, 13-15 October 2020, Timișoara, Romania, ONLINE
3. Gold Medalat Scientific Researcher, Innovation and Inventions Exibition - PRO INVENT, Edition XVIII, 18-20 November 2020, Cluj-Napoca, Romania, ONLINE

For patent application no. A/00700/31.10.2019, Bioactive materials based on hydroxyapatite with antibacterial abilities, A.Vladescu, A.E.Kiss, M.Braic

1. Diploma of Excellence at The 24th International Exhibition of Inventions - INVENTICA 2020, 29 -31 July 2020, Iasi, Romania, ONLINE
2. Gold Medalat International Exhibition for Inventions and Innovations,,TRAIAN  VUIA”, edition VI, 13-15 October 2020, Timișoara, Romania, ONLINE

Papers published in ISI journals

1. Magnesium doped hydroxyapatite-based coatings obtained by pulsed galvanostatic electrochemical deposition with adjustable electrochemical behavior, D.M. Vranceanu, I.C. Ionescu, E. Ungureanu, M.O. Cojocaru, A. Vladescu, C.M. Cotrut, Coatings 10 (2020) 1-15, doi: 10.3390/coatings10080727 (IF2020= 2.881, Q2). 
2. Hydroxyapatite surfaces functionalized with a self-assembling peptide: a XPS, RAIRS and NEXAFS studies, V. Secchi, S. Franchi, M. Dettin, A. Zamuner, K. Beranová, A. Vladescu, C. Battocchio, V. Graziani, L. Tortora, G. Iucci, Nanomaterials 10 (2020) 1151; doi: 10.3390/nano10061151  (IF2019= 5.076, Q1).  Publication error: the no. of project was mistaken at Acknowledgments, being too late for correcting.
3. Evaluation of surface modification techniques on the ability of apatite formation and corrosion behaviour in synthetic body fluid: an in vitro study, C.M. Cotrut, I.C. Ionescu, E.Ungureanu, A.Berbecaru, R.I. Zamfir,  A.Vladescu, D.M. Vranceanu, accepted for publication at 30.11.2020 in Surfaces and Interfaces, 2020 (IF2019= 3.724, Q1). 

Papers published in other journals:

1. Biocompatible coatings used in the field of medicine, A. Vladescu, M. Surmeneva, C.M. Cotrut, R. Surmenev, E. Ungureanu, L.R. Constantin, M. Dinu, V. Brai, volume of Conference  “OPTOELECTRONICS FOR POWERFUL ECONOMY”, 20-23 October 2020, Magurele, Romania – online, Editura AGIR, ISBN 978-973-720-822-4.

Papers presented at international conferences

Invited papers:

1. Sputtered hydroxyapatite coatings used in medicine, A. Vladescu, I. Pana, E. Ungureanu, L. Constantin, C. Vitelaru, The 7th Global Conference on Polymer and Composite Materials (PCM 2020), online conference, 1-4 November 2020, China

Oral presentations:

1. Biocompatible hydroxyapatite-based coatings for medical applications, I. Pana, L. Constantin, E. Ungureanu, A. Vladescu, The 5th International conference "New Trends on Sensing-Monitoring-Telediagnosis for Life Sciences NT-SMT-LS 2020", online conference, 3-4 July 2020, Romania
2. Biodegradable coatings with controllable degradability, A. Vladescu, I. Pana, C. Vitelaru, International Chemical Engineering and Material Symposium, SICHEM 2020, online conference, 17-18 September 2020, Romania
3. In vitro bioactivity and degradation evaluation of biocompatible Ag doped hydroxyapatite coatings, I. Pana, E. Ungureanu, L.R. Constantin, C. M. Cotrut, A. Vladescu, International Chemical Engineering and Material Symposium, SICHEM 2020, online conference, 17-18 September 2020, Romania

Posters:

1. Nanostructured thin films used in industrial applications and/or medicine, A.Vlădescu, A. C.Pârău, C.Vițelaru, I.Pană, L.R.Constantin, THE 24th INTERNATIONAL EXHIBITION OF INVENTIONS INVENTICA - INVENTICA 2020, 29 -31 July 2020, Iasi, Romania, online
2. Bioactive materials based on hydroxyapatite with antibacterial abilities, A. Vladescu, A.E.Kiss, M. Braic, THE 24th INTERNATIONAL EXHIBITION OF INVENTIONS INVENTICA - INVENTICA 2020, 29 -31 July 2020, Iasi, Romania, online
3. Bioactive materials based on hydroxyapatite with antibacterial abilities, A. Vladescu, A.E.Kiss, M. Braic, International Exhibition for Inventions and Innovations ,,TRAIAN  VUIA” Timișoara, edition VI, 13-15 October 2020, Timișoara, Romania, online
4. Nanostructured thin films used in industrial applications and/or medicine, A. Vlădescu, A. C. Pârău, C. Vițelaru, I. Pană, L. R.Constantin, International Exhibition for Inventions and Innovations ,,TRAIAN  VUIA” Timișoara, edition VI, 13-15 October 2020, Timișoara, Romania, online
5. Nanostructured thin films used in industrial applications and/or medicine, A. Vlădescu, A. C. Pârău, C. Vițelaru, I. Pană, L. R.Constantin, Scientific Researcher, Innovation and Inventions Exibition - PRO INVENT, Edition XVIII, 18-20 November 2020, Cluj-Napoca, Romania, online

Consortium meetings

• 11 May 2020 – online meeting; participants: dr. eng. Alina Vladescu (INOE2000)anddr. Julia Kzhyshkowska (University of Heidelberg, Germany).
• 9 November 2020 – online meeting; participants: dr. eng. Alina Vladescu (INOE2000), dr. Julia Kzhyshkowska (University of Heidelberg, Germany) and eng. Jürgen Schmidt (INNOVENT, Germany).
• 10 November 2020 – online meeting; participants:  Coordinator: INOE2000, Romania: Alina Vladescu; Partner 1: Scientific-Production Company «SINTEL», LLC, Russia: Konstantin Prosolov, Olga Nikolaeva; Co-partner 1: Institute of Strength Physics and Materials Science of Siberian Breach of Russian Academy of Sciences (ISPMS of SB RAS), Russia: Yurii Sharkeev; Partner 2: INNOVENT e.V. Technology Development Jena, Germany: Jürgen Schmidt; Partner 3: Riga Technical University, Latvia: Yuri Dekhtyar and Anna Bystrova; Partner 4: University of Heidelberg, Germany: Julia Kzhyshkowska; Partner 5: Kronos Bio, Turkey: Pinar Yilgor Huri, Nesrin Hasirci, Vasif Hasirci, Seyda Gokyer; Partner 6: TEHNOMED IMPEX CO S.A, Romania: Sorin Mihai Croitoru.

All meetings were organized online due to the reinstructions imposed by pandemic Covid-19.

Student projects

Dissertation project – September 2020: Loredana Mihu "Corrosion resistance in biological media of Ti6Al4V alloy deposited by Zn doped HAP based coatings".

Young people involved in project

3 postdocs: C.Vitelaru, M.Dinu, I.Pana
2 PhD students: E. Ungureanu, L. Constantin

Visibility of project

Announcement on LinkedIN of Alina Vladescu:>https://www.linkedin.com/feed/update/urn:li:ugcPost:6699304535552212992/

Announcement on ResearchGate of Alina Vladescu: https://www.researchgate.net/project/CoatDegraBac-project-COFUND-ERANET-RUS-PLUS-68-01082018

Results 2019

Patent application

1. Patent application no.A/00700/31.10.2019, Bioactive materials based on hydroxyapatite with antibacterial abilities, A. Vladescu, A.E. Kiss, M. Braic

Developed Products

Demonstrative implants (Tehnomed Impex SA)

               

Papers published in ISI journals

1.            In vitro evaluation of Ag doped hydroxyapatite coatings in acellular media, D.M. Vranceanu, A.C. Parau, C.M. Cotrut, A.E. Kiss, L.R. Constantin, V. Braic, A. Vladescu, Ceramics International 45 (2019) 11050-11061, doi: 10.1016/j.ceramint.2019.02.191 (IF2019=3.830, Q1).

2.            Investigation of cast and annealed Ti25Nb10Zr alloy as material for orthopedic devices, R. Bolmaro, A.C. Parau, V. Pruna, M.A. Surmeneva, L.R. Constantin, M. Avalos, C.M. Cotrut, R. Tutuianu, M. Braic, D.V. Cojocaru, I. Dan, S. Croitoru, R.A. Surmenev, A. Vladescu, Journal of Material Research and Technology 8 (2019) 3399-3414, doi: 10.1016/j.jmrt.2019.06.006 (IF2019=5.298, Q1).

Papers presented at international conferences 

Invited papers

1. Evaluation of Ag doped hydroxyapatite coatings in three different acellular media: SBF, DMEM and PBS, A. Vladescu, M. Braic, C.M. Cotrut, A. Kiss, (PCM2713), Section No. 6: Medical Applications. 6th Global Conference on Polymer and Composite Materials (PCM 2019)”, 8 - 11 July 2019, Bankok, Thailand.
2. Carbonitride coatings for different applications, A. Vladescu, M. Braic, L.R. Constantin, A.C. Parau, 19th International Balkan Workshop on Applied Physics and Materials Science, 16-19 July 2019, Constanta, Romania.
3. Improvement of antifungal and antibacterial properties of hydroxyapatite coatings by the Ag addition, A.Vladescu, TERMIS EU 2019 „Tissue Engineering Therapies: From Concept to Clinical Translation & Commercialisation”, 27-31 May 2019, Rodos, Grecia.

Consortium meetings

1. 30 May 2019 in Rodos, Greece - Alina Vladescu (INOE 2000, Romania) and Prof. Dr. Julia Kzhyshkowska (University of  Heidelberg, Germany), 27-31 May 2019 – during TERMIS EU 2019 Conference.
2. 23–25 September 2019 in Magurele, Romania - Alina Vladescu (INOE2000), Yurii Sharkeev, Aleksandr Prosolov, Konstantin Prosolov si Dimitrii Mitrichenko (SINTEL, Russia); Dorit Kloss si Jürgen Schmidt (INNOVENT, Germany), Yuri Dekhtyar (Riga Technical University, Latvia), Nesrin Hasirci si Pinar Yilgor Huri (Kronos Bio, Turkey).
3. 28 October 2019 in Magurele, Romania – Alina Vladescu (INOE2000, Romania) and Sorin Croitoru (Tehnomed Impex SA, Romania).

                                                                             

 

Young people involved in project

3 postdocs: C.Vitelaru, M.Dinu, I.Pana
1 PhD student: L.Constantin

Project of students

1. Desertion project – July 2019: Adelina Elena Andries “Evaluation of biomineralization of thin films based on hydroxyapatite doped with Ag using microscopy techniques”
2. Bachelor project – July 2019: Dalila Bivolaru “Comparative study of the in vitro behaviour in various biological environments of different hydroxyapatite based coatings prepared by magnetron sputtering”

Visibility of leader

• Guest Associate Editor, Frontiers in Materials, www.frontiersin.org.
• Guest Associate Editor, Coatings, https://www.mdpi.com/journal/coatings.
• Member of Technical Committee of “6th Global Conference on Polymer and Composite Materials (PCM 2019)”, Bangkok, Thailand, 8 - 11 July 2019.
• Co-organization of Symposium untitled “Immunomodulation” of TERMIS EU 2019 „Tissue Engineering Therapies: From Concept to Clinical Translation & Commercialisation”, Rodos, Grecia, 27-31 May 2019.

Visibility of project

In 13 November 2019, dr. Alina Vladescu was interviewed by Radio Romania Cultural about the objectives of the project. Link of interview: https://radioromaniacultural.ro/materialele-pe-baza-de-mg-si-ti-pentru-implanturi-sunt-mai-bine-tolerate-de-organism-daca-sunt-acoperite-cu-straturi-bioactive-antibacteriene/

Results 2018

 

Papers published in ISI journals

1. In vitro evaluation of Ag doped hydroxyapatite coatings in acellular media - submitted at Ceramics International journal, 2 October 2018 (ID: CERI-D-18-09342).

Consortium meetings

4 May 2018 in Tomsk, Rusia, organized by Russian partner SINTEL. Participants: Dr.ing. Yurii Sharkeev and Dr. Dimitrii Mitrichenko (SINTEL); Alina Vladescu (INOE).

15 November 2018 in Magurele, Romania, organized by INOE. Participants: Dr.ing. Alina Vladescu (INOE) and Sorin Croitoru (Tehnomed).

Young people involved in project

3 postdocs: C.Vitelaru, M.Dinu, I.Pana
1 PhD student: L.Constantin